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COVID-2019 Alert

The latest information about the 2019 Novel Coronavirus, including vaccine clinics for children ages 5 years old and older.

La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 5 años en adelante.

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Lindsey Rasmussen, MD

  • Lindsey K Rasmussen

Specialties

Critical Care Medicine

Work and Education

Professional Education

Medical College Of Wisconsin Office of Graduate Medical Education, Milwaukee, WI, 05/21/2010

Residency

Children's National Medical Center, Washington, DC, 06/30/2013

Fellowship

Johns Hopkins University School of Medicine, Baltimore, MD, 06/30/2016

Board Certifications

Pediatric Critical Care Medicine, American Board of Pediatrics

Pediatrics, American Board of Pediatrics

All Publications

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature Majzner, R. G., Ramakrishna, S., Yeom, K. W., Patel, S., Chinnasamy, H., Schultz, L. M., Richards, R. M., Jiang, L., Barsan, V., Mancusi, R., Geraghty, A. C., Good, Z., Mochizuki, A. Y., Gillespie, S. M., Toland, A. M., Mahdi, J., Reschke, A., Nie, E., Chau, I. J., Rotiroti, M. C., Mount, C. W., Baggott, C., Mavroukakis, S., Egeler, E., Moon, J., Erickson, C., Green, S., Kunicki, M., Fujimoto, M., Ehlinger, Z., Reynolds, W., Kurra, S., Warren, K. E., Prabhu, S., Vogel, H., Rasmussen, L., Cornell, T. T., Partap, S., Fisher, P. G., Campen, C. J., Filbin, M. G., Grant, G., Sahaf, B., Davis, K. L., Feldman, S. A., Mackall, C. L., Monje, M. 2022

Abstract

Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMG) are universally lethal paediatric central nervous system tumours1. We previously discovered that the disialoganglioside GD2 is highly expressed on H3K27M-mutant glioma cells and demonstrated promising preclinical efficacy of GD2-directed chimeric antigen receptor (CAR) T cells2, providing the rationale for a first-in-human Phase 1 clinical trial (NCT04196413). Because CAR T-cell-induced brainstem inflammation can result in obstructive hydrocephalus, increased intracranial pressure, and dangerous tissue shifts, neurocritical care precautions were incorporated. Here we present the clinical experience from the first four patients with H3K27M-mutant DIPG/DMG treated with GD2-CAR T cells (GD2-CART) at dose level 1 (1e6 GD2-CAR T cells/kg administered intravenously). Patients who exhibited clinical benefit were eligible for subsequent GD2-CAR T infusions administered intracerebroventricularly3. Toxicity was largely related to tumor location and reversible with intensive supportive care. On-target, off-tumor toxicity was not observed. Three of four patients exhibited clinical and radiographic improvement. Proinflammatory cytokines were increased in plasma and cerebrospinal fluid (CSF). Transcriptomic analyses of 65,598 single cells from CAR T cell products and CSF elucidate heterogeneity in response between subjects and administration routes. These early results underscore the promise of this approach for H3K27M+ DIPG/DMG therapy.

View details for DOI 10.1038/s41586-022-04489-4

View details for PubMedID 35130560

Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C. Pediatric neurology Fink, E. L., Robertson, C. L., Wainwright, M. S., Roa, J. D., Lovett, M. E., Stulce, C., Yacoub, M., Potera, R. M., Zivick, E., Holloway, A., Nagpal, A., Wellnitz, K., Czech, T., Even, K. M., Brunow de Carvalho, W., Rodriguez, I. S., Schwartz, S. P., Walker, T. C., Campos-Mino, S., Dervan, L. A., Geneslaw, A. S., Sewell, T. B., Pryce, P., Silver, W. G., Lin, J. E., Vargas, W. S., Topjian, A., Alcamo, A. M., McGuire, J. L., Dominguez Rojas, J. A., Munoz, J. T., Hong, S. J., Muller, W. J., Doerfler, M., Williams, C. N., Drury, K., Bhagat, D., Nelson, A., Price, D., Dapul, H., Santos, L., Kahoud, R., Francoeur, C., Appavu, B., Guilliams, K. P., Agner, S. C., Walson, K. H., Rasmussen, L., Janas, A., Ferrazzano, P., Farias-Moeller, R., Snooks, K. C., Chang, C. H., Yun, J., Schober, M. E., Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVID) Investigators 1800; 128: 33-44

Abstract

BACKGROUND: Our objective was to characterize the frequency, early impact, and risk factors for neurological manifestations in hospitalized children with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or multisystem inflammatory syndrome in children (MIS-C).METHODS: Multicenter, cross-sectional study of neurological manifestations in children aged <18years hospitalized with positive SARS-CoV-2 test or clinical diagnosis of a SARS-CoV-2-related condition between January 2020 and April 2021. Multivariable logistic regression to identify risk factors for neurological manifestations was performed.RESULTS: Of 1493 children, 1278 (86%) were diagnosed with acute SARS-CoV-2 and 215 (14%) with MIS-C. Overall, 44% of the cohort (40% acute SARS-CoV-2 and 66% MIS-C) had at least one neurological manifestation. The most common neurological findings in children with acute SARS-CoV-2 and MIS-C diagnosis were headache (16% and 47%) and acute encephalopathy (15% and 22%), both P<0.05. Children with neurological manifestations were more likely to require intensive care unit (ICU) care (51% vs 22%), P<0.001. In multivariable logistic regression, children with neurological manifestations were older (odds ratio [OR] 1.1 and 95% confidence interval [CI] 1.07 to 1.13) and more likely to have MIS-C versus acute SARS-CoV-2 (OR 2.16, 95% CI 1.45 to 3.24), pre-existing neurological and metabolic conditions (OR 3.48, 95% CI 2.37 to 5.15; and OR 1.65, 95% CI 1.04 to 2.66, respectively), and pharyngeal (OR 1.74, 95% CI 1.16 to 2.64) or abdominal pain (OR 1.43, 95% CI 1.03 to 2.00); all P<0.05.CONCLUSIONS: In this multicenter study, 44% of children hospitalized with SARS-CoV-2-related conditions experienced neurological manifestations, which were associated with ICU admission and pre-existing neurological condition. Posthospital assessment for, and support of, functional impairment and neuroprotective strategies are vitally needed.

View details for DOI 10.1016/j.pediatrneurol.2021.12.010

View details for PubMedID 35066369

GD2 CAR T cells mediate clinical activity and manageable toxicity in children and young adults with DIPG and H3K27M-mutated diffuse midline gliomas. Majzner, R. G., Ramakrishna, S., Mochizuki, A., Patel, S., Chinnasamy, H., Yeom, K., Schultz, L., Richards, R., Campen, C., Reschke, A., Mahdi, J., Toland, A., Baggott, C., Mavroukakis, S., Egeler, E., Moon, J., Landrum, K., Erickson, C., Rasmussen, L., Barsan, V., Tamaresis, J. S., Marcy, A., Kunicki, M., Fujimoto, M., Ehlinger, Z., Kurra, S., Cornell, T., Partap, S., Fisher, P., Grant, G., Vogel, H., Sahaf, B., Davis, K., Feldman, S., Mackall, C. L., Monje, M. AMER ASSOC CANCER RESEARCH. 2021
SINGLE CELL RNA SEQUENCING FROM THE CSF OF SUBJECTS WITH H3K27M+DIPG/DMG TREATED WITH GD2 CAR T-CELLULAR THERAPY Mochizuki, A., Ramakrishna, S., Good, Z., Patel, S., Chinnasamy, H., Yeom, K., Schultz, L., Richards, R., Campen, C., Reschke, A., Mahdi, J., Toland, A., Baggot, C., Mavroukakis, S., Egeler, E., Moon, J., Landrum, K., Erickson, C., Rasmussen, L., Barsan, V., Tamaresis, J., Marcy, A., Kunicki, M., Celones, M., Ehlinger, Z., Kurra, S., Cornell, T., Partap, S., Fisher, P., Grant, G., Vogel, H., Davis, K., Feldman, S., Sahaf, B., Majzner, R., Mackall, C., Monje, M. OXFORD UNIV PRESS INC. 2021: 39
Sedation and Analgesia in Brain-Injured Children Sedation and Analgesia for the Pediatric Intensivist: A Clinical Guide Rasmussen, L. Springer. 2020; 1
NAUSEA AND VOMITING AFTER CRANIOTOMY IN THE PEDIATRIC ICU: INCIDENCE AND VARIATIONS IN PRACTICE Chang, N., Duethman, L., Young, N., Rasmussen, L. LIPPINCOTT WILLIAMS & WILKINS. 2020

Abstract

The aim of this study was to evaluate the current infrastructure and practice characteristics of pediatric extracorporeal membrane oxygenation (ECMO) programs. A 40-question survey of center-specific demographics, practice structure, program experience, and support network utilized to cannulate and maintain a pediatric patient on ECMO was designed via a web-based survey tool. The survey was distributed to pediatric ECMO programs in the United States and Canada. Of the 101 centers that were identified to participate, 41 completed the survey. The majority of responding centers are university affiliated (73%) and have an intensive care unit (ICU) with 15-25 beds (58%). Extracorporeal membrane oxygenation has been offered for >10 years in 85% of the centers. The median number of total cannulations per center in 2017 was 15 (interquartile range [IQR] = 5-30), with the majority occurring in the cardiovascular intensive care unit (median = 13, IQR = 5-25). Fifty-seven percent of responding centers offer ECPR, with a median number of four cases per year (IQR = 2-7). Most centers cannulate in an operating room or ICU; 11 centers can cannulate in the pediatric ED. Sixty-three percent of centers have standardized protocols for postcannulation management. The majority of protocols guide anticoagulation, sedation, or ventilator management; left ventricle decompression and reperfusion catheter placement are the least standardized procedures. The majority of pediatric ECMO centers have adopted the infrastructure recommendations from the Extracorporeal Life Support Organization. However, there remains broad variability of practice characteristics and organizational infrastructure for pediatric ECMO centers across the United States and Canada.

View details for DOI 10.1097/MAT.0000000000001311

View details for PubMedID 33181543

Characteristics of Pediatric Extracorporeal Membrane Oxygenation Programs in the United States and Canada. ASAIO journal (American Society for Artificial Internal Organs : 1992) Troy, L. n., Su, F. n., Kilbaugh, T. n., Rasmussen, L. n., Kuo, T. n., Jett, E. n., Cornell, T. n., Berg, M. n., Haileselassie, B. n. 2020
Infrastructure and Practice Characteristics of Pediatric ECMO Programs in the US and Canada Society of Critical Care Medicine Troy , L., Su, F., Berg, M., Rasmussen , L., Kuo, T., Jett, E., Jacobs, K., Haileselassie , B. 2019
INFRASTRUCTURE AND PRACTICE CHARACTERISTICS OF PEDIATRIC ECMO PROGRAMS ACROSS NORTH AMERICA Troy, L., Su, F., Berg, M., Rasmussen, L., Kuo, T., Jett, E., Jacobs, K., Haileselassie, B. LIPPINCOTT WILLIAMS & WILKINS. 2019
Trauma Bay Disposition of Infants and Young Children With Mild Traumatic Brain Injury and Positive Head Imaging Pediatric Critical Care Medicine Noje, C., Jackson, E., Nasr, I., Costabile, P., Cerullo, M., Hoops, K., Rasmussen, L., Henderson, E., Ziegfeld, S., Puett, L., Robertson , C. 2019

Abstract

This article aims to describe a rare cause of severe encephalitis in 2 cases of infants with signs of intracranial hypertension and severe autonomic dysregulation. The authors conclude that human parechoviruses are becoming a more recognized cause of encephalitis because of the increasing use of rapid detection methods. With early recognition of this clinical entity, improved care can be administered.

View details for DOI 10.1177/0883073818789317

View details for Web of Science ID 000444976000007

View details for PubMedID 30105932

A Case Series of Parechovirus Encephalopathy: Apnea and Autonomic Dysregulation in Critically Ill Infants JOURNAL OF CHILD NEUROLOGY Ristagno, E. H., Bhalla, S. C., Rasmussen, L. K. 2018; 33 (12): 78893
Traumatic Injury Leads to Inflammation and Altered Tryptophan Metabolism in the Juvenile Rabbit Brain JOURNAL OF NEUROTRAUMA Zhang, Z., Rasmussen, L., Saraswati, M., Koehler, R. C., Robertson, C., Kannan, S. 2019; 36 (1): 7486

Abstract

Introduction. Human metapneumovirus (HMPV) is a paramyxovirus from the same subfamily as respiratory syncytial virus (RSV) and causes similar acute lower respiratory tract infection. Albuterol in the setting of acute RSV infection is controversial and has not yet been studied in HMPV. We sought to determine the frequency of albuterol use in HMPV infection and the association between albuterol administration and patient outcomes. Methods. We conducted a retrospective cohort study identifying all patients hospitalized in a tertiary care children's hospital with laboratory-confirmed HMPV infection between January 2010 and December 2010. Results. There were 207 patients included in the study; 57% had a chronic medical condition. The median hospital length of stay was 3 days. Only 31% of patients in the study had a documented wheezing history, while 69% of patients received at least one albuterol treatment. There was no difference in length of stay between patients who received albuterol and those who did not. Conclusion. There is a high frequency of albuterol use in children hospitalized with HMPV infection. As with RSV, evidence may not support routine use of bronchodilators in patients with acute HMPV respiratory infection. Research involving additional patient outcomes and illness severity indicators would be useful in future studies.

View details for PubMedID 26925109

View details for PubMedCentralID PMC4748140

Neurocritical Care for Severe Pediatric Traumatic Brain Injury Rasmussen, L., Raghupathi, R., Lang Chen , S., Huh, J., Su, F. Medscap Drugs and Diseases. 2018
Albuterol Use in Children Hospitalized with Human Metapneumovirus Respiratory Infection INTERNATIONAL JOURNAL OF PEDIATRICS Rasmussen, L. K., Schuette, J., Spaeder, M. C. 2016: 7021943
PERIPHERAL IMMUNE RESPONSE AFTER PEDIATRIC TRAUMATIC BRAIN INJURY IN RABBIT Rasmussen, L., Zhang, Z., Saraswati, M., Kannan, S., Robertson, C. MARY ANN LIEBERT, INC. 2015: A88